Endoplasmic Reticulum Stress Induces Fibrogenic Activity in Hepatic Stellate Cells through Autophagy

BACKGROUND & AIMS: Metabolic stress during liver injury enhances autophagy and provokes stellate cell activation, with secretion of scar matrix. Conditions that augment protein synthesis increase demands on the endoplasmic reticulum (ER) folding capacity and trigger the unfolded protein response...

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Detalhes bibliográficos
Main Authors: Hernández-Gea, Virginia, Hilscher, Moira, Rozenfeld, Raphael, Lim, Maribel P, Nieto, Natalia, Werner, Sabine, Devi, Lakshmi A., Friedman, Scott L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686909/
https://ncbi.nlm.nih.gov/pubmed/23485523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2013.02.016
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