Endoplasmic Reticulum Stress Induces Fibrogenic Activity in Hepatic Stellate Cells through Autophagy

BACKGROUND & AIMS: Metabolic stress during liver injury enhances autophagy and provokes stellate cell activation, with secretion of scar matrix. Conditions that augment protein synthesis increase demands on the endoplasmic reticulum (ER) folding capacity and trigger the unfolded protein response...

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Bibliografiset tiedot
Päätekijät: Hernández-Gea, Virginia, Hilscher, Moira, Rozenfeld, Raphael, Lim, Maribel P, Nieto, Natalia, Werner, Sabine, Devi, Lakshmi A., Friedman, Scott L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686909/
https://ncbi.nlm.nih.gov/pubmed/23485523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2013.02.016
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