Suppression of Induced microRNA-15b Prevents Rapid Loss of Cardiac Function in a Dicer Depleted Model of Cardiac Dysfunction

BACKGROUND: Dicer endonuclease, critical for maturation of miRNAs, is depleted in certain forms of cardiomyopathy which results in differential expression of certain microRNAs. We sought to elucidate the mechanisms underlying the rapid loss of cardiac function following cardiac-specific Dicer deplet...

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Autors principals: Roy, Sashwati, Banerjee, Jaideep, Gnyawali, Surya C., Khanna, Savita, He, Guanglong, Pfeiffer, Douglas, Zweier, Jay L., Sen, Chandan K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686742/
https://ncbi.nlm.nih.gov/pubmed/23840532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066789
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