Epigenetic Modification of MicroRNA-200b Contributes to Diabetic Vasculopathy

Hyperglycemia (HG) induces genome-wide cytosine demethylation. Our previous work recognized miR-200b as a critical angiomiR, which must be transiently downregulated to initiate wound angiogenesis. Under HG, miR-200b downregulation is not responsive to injury. Here, we demonstrate that HG may drive v...

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Publicado en:Mol Ther
Main Authors: Singh, Kanhaiya, Pal, Durba, Sinha, Mithun, Ghatak, Subhadip, Gnyawali, Surya C., Khanna, Savita, Roy, Sashwati, Sen, Chandan K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768662/
https://ncbi.nlm.nih.gov/pubmed/29037594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.09.009
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