Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue

Inflammation, following injury, induces cellular plasticity as an inherent component of physiological tissue repair. The dominant fate of wound macrophages is unclear and debated. Here we show that two-thirds of all granulation tissue fibroblasts, otherwise known to be of mesenchymal origin, are der...

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Udgivet i:Nat Commun
Main Authors: Sinha, Mithun, Sen, Chandan K., Singh, Kanhaiya, Das, Amitava, Ghatak, Subhadip, Rhea, Brian, Blackstone, Britani, Powell, Heather M., Khanna, Savita, Roy, Sashwati
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838200/
https://ncbi.nlm.nih.gov/pubmed/29507336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03208-w
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