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GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors

Most breast cancers at diagnosis are estrogen receptor (ER)-positive and depend on estrogen for growth and survival. Blocking estrogen biosynthesis by aromatase inhibitors (AI) has therefore become a first-line endocrine therapy for post-menopausal women with ER-positive breast cancers. Despite prov...

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Detalhes bibliográficos
Main Authors: Morandi, Andrea, Martin, Lesley-Ann, Gao, Qiong, Pancholi, Sunil, Mackay, Alan, Robertson, David, Zvelebil, Marketa, Dowsett, Mitch, Plaza-Menacho, Ivan, Isacke, Clare M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686594/
https://ncbi.nlm.nih.gov/pubmed/23650283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4265
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