Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancer

BACKGROUND: Therapies targeting estrogenic stimulation in estrogen receptor-positive (ER+) breast cancer (BC) reduce mortality, but resistance remains a major clinical problem. Molecular studies have shown few high-frequency mutations to be associated with endocrine resistance. In contrast, expressi...

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Veröffentlicht in:Breast Cancer Res
Hauptverfasser: Simigdala, Nikiana, Gao, Qiong, Pancholi, Sunil, Roberg-Larsen, Hanne, Zvelebil, Marketa, Ribas, Ricardo, Folkerd, Elizabeth, Thompson, Andrew, Bhamra, Amandeep, Dowsett, Mitch, Martin, Lesley-Ann
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888666/
https://ncbi.nlm.nih.gov/pubmed/27246191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-016-0713-5
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