Acetylation is indispensable for p53 antiviral activity

Tumor suppressor p53 is known to be a direct transcriptional target of type I interferons (IFNs), contributing to virus-induced apoptosis, and in turn activating itself the interferon pathway. Acetylation, among many other post-translational modifications of p53, is thought to exert a crucial role r...

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Autores principales: Muñoz-Fontela, Cesar, González, Dolores, Marcos-Villar, Laura, Campagna, Michela, Gallego, Pedro, González-Santamaría, José, Herranz, Daniel, Gu, Wei, Serrano, Manuel, Aaronson, Stuart A., Rivas, Carmen
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2011
Materias:
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685621/
https://ncbi.nlm.nih.gov/pubmed/22033337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.21.17899
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