Natriuretic Peptide Receptor-3 Gene (NPR3) Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation

BACKGROUND: The primary role of natriuretic peptide receptor-3 (NPR3) or NPR-C is in the clearance of natriuretic peptides that play an important role in modulating intravascular volume and vascular tone. Genetic variation in NPR3 has been associated with variation in blood pressure and obesity. Des...

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Main Authors: Pereira, Naveen L., Lin, Dong, Pelleymounter, Linda, Moon, Irene, Stilling, Gail, Eckloff, Bruce W., Wieben, Eric D., Redfield, Margaret M., Burnett, John C., Yee, Vivien C., Weinshilboum, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685298/
https://ncbi.nlm.nih.gov/pubmed/23493048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.112.964742
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