INHIBITION OF THE HEDGEHOG PATHWAY TARGETS THE TUMOR-ASSOCIATED STROMA IN PANCREATIC CANCER

The Hedgehog (Hh) pathway has emerged as an important pathway in multiple tumor types and is thought to be dependent on a paracrine signaling mechanism. The purpose of this study was to determine the role of pancreatic cancer-associated fibroblasts (human pancreatic stellate cells, HPSCs) in Hh sign...

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Hlavní autoři: Hwang, Rosa F., Moore, Todd T., Hattersley, Maureen Mertens, Scarpitti, Meghan, Yang, Bin, Devereaux, Erik, Ramachandran, Viji, Arumugam, Thiru, Ji, Baoan, Logsdon, Craig D., Brown, Jeffrey L., Godin, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685283/
https://ncbi.nlm.nih.gov/pubmed/22859707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0022
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