Animal Models of Gastrointestinal and Liver Diseases. The difficulty of animal modeling of pancreatic cancer for preclinical evaluation of therapeutics

Pancreatic ductal adenocarcinoma (PDAC) is relatively rare but extremely lethal. Standard cytotoxic therapeutics provide little benefit. To date, newer targeted therapeutics have also not been highly successful. Often novel therapeutics that have appeared to perform well in preclinical models have f...

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Bibliographic Details
Published in:Am J Physiol Gastrointest Liver Physiol
Main Authors: Logsdon, Craig D., Arumugam, Thiruvengadam, Ramachandran, Vijaya
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556944/
https://ncbi.nlm.nih.gov/pubmed/26159697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00169.2015
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