Progressive Multifocal Leukoencephalopathy-Associated Mutations in the JC Polyomavirus Capsid Disrupt Lactoseries Tetrasaccharide c Binding

The human JC polyomavirus (JCPyV) is the causative agent of the fatal, demyelinating disease progressive multifocal leukoencephalopathy (PML). The Mad-1 prototype strain of JCPyV uses the glycan lactoseries tetrasaccharide c (LSTc) and serotonin receptor 5-HT(2A) to attach to and enter into host cel...

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Main Authors: Maginnis, Melissa S., Ströh, Luisa J., Gee, Gretchen V., O’Hara, Bethany A., Derdowski, Aaron, Stehle, Thilo, Atwood, Walter J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Microbiology 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685208/
https://ncbi.nlm.nih.gov/pubmed/23760462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00247-13
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