Global regulation of promoter melting in naïve lymphocytes

Lymphocyte activation is initiated by a global increase in mRNA synthesis. However, the mechanisms driving transcriptome amplification during the immune response are unknown. By monitoring ssDNA genome-wide, we show that the genome of naïve cells is poised for rapid activation. In G0, ~90% of promot...

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Detalhes bibliográficos
Main Authors: Kouzine, Fedor, Wojtowicz, Damian, Yamane, Arito, Resch, Wolfgang, Kieffer-Kwon, Kyong-Rim, Bandle, Russell, Nelson, Steevenson, Nakahashi, Hirotaka, Awasthi, Parirokh, Feigenbaum, Lionel, Menoni, Herve, Hoeijmakers, Jan, Vermeulen, Wim, Ge, Hui, Przytycka, Teresa M., Levens, David, Casellas, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684982/
https://ncbi.nlm.nih.gov/pubmed/23706737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.04.033
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