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Global regulation of promoter melting in naïve lymphocytes
Lymphocyte activation is initiated by a global increase in mRNA synthesis. However, the mechanisms driving transcriptome amplification during the immune response are unknown. By monitoring ssDNA genome-wide, we show that the genome of naïve cells is poised for rapid activation. In G0, ~90% of promot...
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| Главные авторы: | , , , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3684982/ https://ncbi.nlm.nih.gov/pubmed/23706737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.04.033 |
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