Similar dose-dependence of motor neuron cell death caused by wild type human TDP-43 and mutants with ALS-associated amino acid substitutions

Antzeko izenburuak

• Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS
  nork: Mitchell, Jacqueline C, et al.
  Argitaratua: (2015)
• A robust TDP-43 knock-in mouse model of ALS
  nork: Huang, Shih-Ling, et al.
  Argitaratua: (2020)
• Targeted Depletion of TDP-43 Expression in the Spinal Cord Motor Neurons Leads to the Development of Amyotrophic Lateral Sclerosis-like Phenotypes in Mice
  nork: Wu, Lien-Szu, et al.
  Argitaratua: (2012)
• Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats
  nork: Huang, Cao, et al.
  Argitaratua: (2011)
• Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats
  nork: Tong, Jianbin, et al.
  Argitaratua: (2013)