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A robust TDP-43 knock-in mouse model of ALS
Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset degenerative disorder of motor neurons. The diseased spinal cord motor neurons of more than 95% of amyotrophic lateral sclerosis (ALS) patients are characterized by the mis-metabolism of the RNA/DNA-binding protein TDP-43 (ALS-TDP), in part...
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| Publicado no: | Acta Neuropathol Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6975031/ https://ncbi.nlm.nih.gov/pubmed/31964415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-0881-5 |
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