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Structural and Functional Basis of CXCL12 (Stromal Cell-derived Factor-1α) Binding to Heparin
CXCL12 (SDF-1α) and CXCR4 are critical for embryonic development and cellular migration in adults. These proteins are involved in HIV-1 infection, cancer metastasis, and WHIM disease. Sequestration and presentation of CXCL12 to CXCR4 by glycosaminoglycans (GAGs) is proposed to be important for recep...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3684283/ https://ncbi.nlm.nih.gov/pubmed/17264079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M608796200 |
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