Altered regional cardiac wall mechanics are associated with differential cardiomyocyte calcium handling due to nebulette mutations in preclinical inherited dilated cardiomyopathy

BACKGROUND: Nebulette (NEBL) is a sarcomeric Z-disc protein involved in mechanosensing and force generation via its interaction with actin and tropomyosin-troponin complex. Genetic abnormalities in NEBL lead to dilated cardiomyopathy (DCM) in humans and animal models. OBJECTIVES: To determine the ea...

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Main Authors: Maiellaro-Rafferty, K, Wansapura, JP, Mendsaikhan, U, Osinska, H, James, J, Taylor, MD, Robbins, J, Kranias, EG, Towbin, JA, Purevjav, E
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683841/
https://ncbi.nlm.nih.gov/pubmed/23632046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.04.021
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