Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

Recent molecular studies have revealed that, even when derived from a seemingly homogenous population, individual cells can exhibit substantial differences in gene expression, protein levels, and phenotypic output(1–5), with important functional consequences(4,5). Existing studies of cellular hetero...

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Hauptverfasser: Shalek, Alex K., Satija, Rahul, Adiconis, Xian, Gertner, Rona S., Gaublomme, Jellert T., Raychowdhury, Raktima, Schwartz, Schragi, Yosef, Nir, Malboeuf, Christine, Lu, Diana, Trombetta, John T., Gennert, Dave, Gnirke, Andreas, Goren, Alon, Hacohen, Nir, Levin, Joshua Z., Park, Hongkun, Regev, Aviv
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683364/
https://ncbi.nlm.nih.gov/pubmed/23685454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12172
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