Single-cell Genomics Unveils Critical Regulators of Th17 cell Pathogenicity

Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...

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Bibliographic Details
Published in:Cell
Main Authors: Gaublomme, Jellert T., Yosef, Nir, Lee, Youjin, Gertner, Rona S., Yang, Li V., Wu, Chuan, Pandolfi, Pier Paolo, Mak, Tak, Satija, Rahul, Shalek, Alex K., Kuchroo, Vijay K., Park, Hongkun, Regev, Aviv
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671824/
https://ncbi.nlm.nih.gov/pubmed/26607794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.11.009
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