Single-cell Genomics Unveils Critical Regulators of Th17 cell Pathogenicity

Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Gaublomme, Jellert T., Yosef, Nir, Lee, Youjin, Gertner, Rona S., Yang, Li V., Wu, Chuan, Pandolfi, Pier Paolo, Mak, Tak, Satija, Rahul, Shalek, Alex K., Kuchroo, Vijay K., Park, Hongkun, Regev, Aviv
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671824/
https://ncbi.nlm.nih.gov/pubmed/26607794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.11.009
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