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Probing the stabilizing effects of modified nucleotides in the bacterial decoding region of 16S ribosomal RNA

The bacterial decoding region of 16S ribosomal RNA has multiple modified nucleotides. In order to study the role of N(4),2′-O-dimethylcytidine (m(4)Cm), the corresponding phosphoramidite was synthesized utilizing 5′-silyl-2′-ACE chemistry. Using solid-phase synthesis, m(4)Cm, 5-methylcytidine (m(5)C...

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Detalhes bibliográficos
Main Authors: Mahto, Santosh K., Chow, Christine S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683315/
https://ncbi.nlm.nih.gov/pubmed/23566761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.03.010
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