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Probing the stabilizing effects of modified nucleotides in the bacterial decoding region of 16S ribosomal RNA

The bacterial decoding region of 16S ribosomal RNA has multiple modified nucleotides. In order to study the role of N(4),2′-O-dimethylcytidine (m(4)Cm), the corresponding phosphoramidite was synthesized utilizing 5′-silyl-2′-ACE chemistry. Using solid-phase synthesis, m(4)Cm, 5-methylcytidine (m(5)C...

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Autors principals: Mahto, Santosh K., Chow, Christine S.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683315/
https://ncbi.nlm.nih.gov/pubmed/23566761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.03.010
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