Long-Term Stabilization Effects of Leptin on Brain Functions in a Leptin-Deficient Patient

CONTEXT: Congenital leptin deficiency, caused by a very rare mutation in the gene encoding leptin, leads to severe obesity, hyperphagia and impaired satiety. The only systemic treatment is the substitution with metreleptin leading to weight reduction based on hormonal changes. Several studies have a...

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Bibliografiske detaljer
Main Authors: Frank, Sabine, Heni, Martin, Moss, Anja, von Schnurbein, Julia, Farooqi, Sadaf, Häring, Hans-Ulrich, Fritsche, Andreas, Preissl, Hubert, Wabitsch, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683048/
https://ncbi.nlm.nih.gov/pubmed/23799059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065893
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