Long-Term Stabilization Effects of Leptin on Brain Functions in a Leptin-Deficient Patient

CONTEXT: Congenital leptin deficiency, caused by a very rare mutation in the gene encoding leptin, leads to severe obesity, hyperphagia and impaired satiety. The only systemic treatment is the substitution with metreleptin leading to weight reduction based on hormonal changes. Several studies have a...

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Main Authors: Frank, Sabine, Heni, Martin, Moss, Anja, von Schnurbein, Julia, Farooqi, Sadaf, Häring, Hans-Ulrich, Fritsche, Andreas, Preissl, Hubert, Wabitsch, Martin
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683048/
https://ncbi.nlm.nih.gov/pubmed/23799059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065893
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