Zinc Finger Nuclease Mediated Knockout of ADP-Dependent Glucokinase in Cancer Cell Lines: Effects on Cell Survival and Mitochondrial Oxidative Metabolism

Zinc finger nucleases (ZFN) are powerful tools for editing genes in cells. Here we use ZFNs to interrogate the biological function of ADPGK, which encodes an ADP-dependent glucokinase (ADPGK), in human tumour cell lines. The hypothesis we tested is that ADPGK utilises ADP to phosphorylate glucose un...

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Detalhes bibliográficos
Main Authors: Richter, Susan, Morrison, Shona, Connor, Tim, Su, Jiechuang, Print, Cristin G., Ronimus, Ron S., McGee, Sean L., Wilson, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683018/
https://ncbi.nlm.nih.gov/pubmed/23799003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065267
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