Up-regulation of thromboxane A(2) impairs cerebrovascular eNOS function in aging atherosclerotic mice

We previously reported that in healthy mouse cerebral arteries, endothelial nitric oxide synthase (eNOS) produces H(2)O(2), leading to endothelium-dependent dilation. In contrast, thromboxane A(2) (TXA(2)), a potent pro-oxidant and pro-inflammatory endogenous vasoconstrictor, is associated with eNOS...

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Huvudupphovsmän: Drouin, Annick, Farhat, Nada, Bolduc, Virginie, Thorin-Trescases, Nathalie, Gillis, Marc-Antoine, Villeneuve, Louis, Nguyen, Albert, Thorin, Eric
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682985/
https://ncbi.nlm.nih.gov/pubmed/21617900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-011-0973-y
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