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Up-regulation of thromboxane A(2) impairs cerebrovascular eNOS function in aging atherosclerotic mice
We previously reported that in healthy mouse cerebral arteries, endothelial nitric oxide synthase (eNOS) produces H(2)O(2), leading to endothelium-dependent dilation. In contrast, thromboxane A(2) (TXA(2)), a potent pro-oxidant and pro-inflammatory endogenous vasoconstrictor, is associated with eNOS...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3682985/ https://ncbi.nlm.nih.gov/pubmed/21617900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-011-0973-y |
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