Hyaluronan fragments induce IFNβ via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway

BACKGROUND: The extracellular matrix plays a critical role in insuring tissue integrity and water homeostasis. However, breakdown products of the extracellular matrix have emerged as endogenous danger signals, designed to rapidly activate the immune system against a potential pathogen breach. Type I...

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Main Authors: Black, Katharine E, Collins, Samuel L, Hagan, Robert S, Hamblin, Mark J, Chan-Li, Yee, Hallowell, Robert W, Powell, Jonathan D, Horton, Maureen R
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682892/
https://ncbi.nlm.nih.gov/pubmed/23721397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-10-23
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