Suppression of Autophagy in Osteocytes Mimics Skeletal Aging

Bone mass declines with age but the mechanisms responsible remain unclear. Here we demonstrate that deletion of a conditional allele for Atg7, a gene essential for autophagy, from osteocytes caused low bone mass in 6-month-old male and female mice. Cancellous bone volume and cortical thickness were...

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Hlavní autoři: Onal, Melda, Piemontese, Marilina, Xiong, Jinhu, Wang, Yiying, Han, Li, Ye, Shiqiao, Komatsu, Masaaki, Selig, Martin, Weinstein, Robert S., Zhao, Haibo, Jilka, Robert L., Almeida, Maria, Manolagas, Stavros C., O'Brien, Charles A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682543/
https://ncbi.nlm.nih.gov/pubmed/23645674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.444190
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