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PRMT1 methylates the single Argonaute of Toxoplasma gondii and is important for the recruitment of Tudor nuclease for target RNA cleavage by antisense guide RNA

Argonaute (Ago) plays a central role in RNA interference in metazoans, but its status in lower organisms remains ill-defined. We report on the Ago complex of the unicellular protozoan, Toxoplasma gondii (Tg), an obligatory pathogen of mammalian hosts. The PIWI-like domain of TgAgo lacked the canonic...

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Detalles Bibliográficos
Autores principales: Musiyenko, Alla, Majumdar, Tanmay, Andrews, Joel, Adams, Brian, Barik, Sailen
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682492/
https://ncbi.nlm.nih.gov/pubmed/22309152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1462-5822.2012.01763.x
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