Laddar...

Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis

OBJECTIVE: Hereditary pancreatitis is caused by mutations in human cationic trypsinogen (PRSS1) which lead to increased autoactivation by altering chymotrypsin C (CTRC)-dependent trypsinogen activation and degradation. Exceptions are some cysteine mutations which cause misfolding, intracellular rete...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Schnúr, Andrea, Beer, Sebastian, Witt, Heiko, Hegyi, Péter, Sahin-Tóth, Miklós
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681892/
https://ncbi.nlm.nih.gov/pubmed/23455445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2012-304331
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!