Immunization of Aged Pigs with Attenuated Pseudorabies Virus Vaccine Combined with CpG Oligodeoxynucleotide Restores Defective Th1 Immune Responses

BACKGROUND AND AIMS: Attempts to immunize aged subjects often result in the failure to elicit a protective immune response. Murine model studies have shown that oligonucleotides containing CpG motifs (CpG ODN) can stimulate immune system in aged mice as effectively as in young mice. Since many physi...

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Detalhes bibliográficos
Main Authors: Ming, Feiping, Yang, Jun, Chu, Pinpin, Ma, Miaopeng, Shi, Juqing, Cai, Haiming, Huang, Chaoyuan, Li, Huazhou, Jiang, Zhenggu, Wang, Houguang, Wang, Weifang, Zhang, Shuiqing, Zhang, Linghua
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681863/
https://ncbi.nlm.nih.gov/pubmed/23785433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065536
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