TALEN-mediated editing of the Mouse Y Chromosome

The functional study of Y chromosome genes has been hindered by a lack of mouse models with specific Y chromosome mutations. We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to produce mice with targeted gene disruptions and i...

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Detalhes bibliográficos
Main Authors: Wang, Haoyi, Hu, Yueh-Chiang, Markoulaki, Styliani, Welstead, G. Grant, Cheng, Albert W., Shivalila, Chikdu S., Pyntikova, Tatyana, Dadon, Daniel B., Voytas, Daniel F., Bogdanove, Adam J., Page, David C., Jaenisch, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681814/
https://ncbi.nlm.nih.gov/pubmed/23666012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2595
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