A Loss-of-Function Screen for Phosphatases that Regulate Neurite Outgrowth Identifies PTPN12 as a Negative Regulator of TrkB Tyrosine Phosphorylation

Alterations in function of the neurotrophin BDNF are associated with neurodegeneration, cognitive decline, and psychiatric disorders. BDNF promotes axonal outgrowth and branching, regulates dendritic tree morphology and is important for axonal regeneration after injury, responses that largely result...

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Detalhes bibliográficos
Main Authors: Ambjørn, Malene, Dubreuil, Véronique, Miozzo, Federico, Nigon, Fabienne, Møller, Bente, Issazadeh-Navikas, Shohreh, Berg, Jacob, Lees, Michael, Sap, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681791/
https://ncbi.nlm.nih.gov/pubmed/23785422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065371
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