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Kalirin is Required for BDNF-TrkB Stimulated Neurite Outgrowth and Branching
Exogenous brain-derived neurotrophic factor (BDNF), acting through TrkB, is known to promote neurite formation and branching. This response to BDNF was eliminated by inhibition of TrkB kinase and by specific inhibition of the GEF1 domain of Kalirin, which activates Rac1. Neurons from Kalrn knockout...
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| Veröffentlicht in: | Neuropharmacology |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4912856/ https://ncbi.nlm.nih.gov/pubmed/27036892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.03.050 |
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