IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance to intracellular pathogenic microbes. IRGs and GBPs stably associate with pathogen-containing vacuoles (PVs) and elicit immune pathways directed at the targeted vacuoles....

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Detalhes bibliográficos
Main Authors: Haldar, Arun K., Saka, Hector A., Piro, Anthony S., Dunn, Joe Dan, Henry, Stanley C., Taylor, Gregory A., Frickel, Eva M., Valdivia, Raphael H., Coers, Jörn
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681737/
https://ncbi.nlm.nih.gov/pubmed/23785284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003414
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