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RNA polymerase II transcription factors H4TF-1 and H4TF-2 require metal to bind specific DNA sequences.

Specific DNA-binding and in vitro transcription activities of H4TF-1 and H4TF-2 are inactivated by chelating agents. Binding activity is restored by addition of Zn2+, and H4TF-2 is also reactivated by Fe2+. In contrast, preformed factor-DNA complexes are resistant to chelators. Therefore, metal ions...

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Bibliografiske detaljer
Main Authors: Dailey, L, Roberts, S B, Heintz, N
Format: Artigo
Sprog:Inglês
Udgivet: 1987
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC368148/
https://ncbi.nlm.nih.gov/pubmed/3437898
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