RNA polymerase II transcription factors H4TF-1 and H4TF-2 require metal to bind specific DNA sequences.

Specific DNA-binding and in vitro transcription activities of H4TF-1 and H4TF-2 are inactivated by chelating agents. Binding activity is restored by addition of Zn2+, and H4TF-2 is also reactivated by Fe2+. In contrast, preformed factor-DNA complexes are resistant to chelators. Therefore, metal ions...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Dailey, L, Roberts, S B, Heintz, N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368148/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3437898/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.7.12.4582-4584.1987
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