Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway

BACKGROUND: Mechanical forces regulate cell behavior and function during development, differentiation, and tissue morphogenesis. In the vascular system, forces produced by blood flow are critical determinants not only of morphogenesis and function, but also pathological states such as atherosclerosi...

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Detalhes bibliográficos
Main Authors: Collins, Caitlin, Guilluy, Christophe, Welch, Christopher, O’Brien, E. Timothy, Hahn, Klaus, Superfine, Richard, Burridge, Keith, Tzima, Ellie
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681294/
https://ncbi.nlm.nih.gov/pubmed/23084990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.08.051
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