Upregulation of the E3 ligase NEDD4-1 by Oxidative Stress Degrades IGF-1 Receptor Protein in Neurodegeneration

The importance of ubiquitin E3 ligases in neurodegeneration is being increasingly recognized. The crucial role of NEDD4-1 in neural development is well appreciated; however, its role in neurodegeneration remains unexplored. Herein, we report increased NEDD4-1 expression in the degenerated tissues of...

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Autori principali: Kwak, Young-Don, Wang, Bin, Li, Jing Jing, Wang, Ruishan, Deng, Qiyue, Diao, Shiyong, Chen, Yaomin, Xu, Raymond, Masliah, Eliezer, Xu, Huaxi, Sung, Jung-Joon, Liao, Francesca-Fang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681290/
https://ncbi.nlm.nih.gov/pubmed/22875931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1836-12.2012
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