Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability

Amyotrophic lateral sclerosis (ALS) is a devastating paralytic disorder caused by dysfunction and degeneration of motoneurons starting in adulthood. Recent studies using cell or animal models document that astrocytes expressing disease-causing mutations of human superoxide dismutase 1 (hSOD1) contri...

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Hlavní autoři: Fritz, Elsa, Izaurieta, Pamela, Weiss, Alexandra, Mir, Franco R., Rojas, Patricio, Gonzalez, David, Rojas, Fabiola, Brown, Robert H., Madrid, Rodolfo, van Zundert, Brigitte
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680799/
https://ncbi.nlm.nih.gov/pubmed/23486205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00500.2012
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