Collapsin Response Mediator Protein 4a (CRMP4a) Is Upregulated in Motoneurons of Mutant SOD1 Mice and Can Trigger Motoneuron Axonal Degeneration and Cell Death

Embryonic motoneurons from mutant SOD1 (mSOD1) mouse models of amyotrophic lateral sclerosis (ALS), but not wild-type motoneurons, can be triggered to die by exposure to nitric oxide (NO), leading to activation of a motoneuron-specific signaling pathway downstream of the death receptor Fas/CD95. To...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Duplan, Laure, Bernard, Nathalie, Casseron, Wilfrid, Dudley, Keith, Thouvenot, Eric, Honnorat, Jérôme, Rogemond, Véronique, De Bovis, Béatrice, Aebischer, Patrick, Marin, Philippe, Raoul, Cédric, Henderson, Christopher E., Pettmann, Brigitte
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633025/
https://ncbi.nlm.nih.gov/pubmed/20071543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5411-09.2010
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