IFNγ triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that primarily affects motoneurons in the brain and spinal cord. Dominant mutations in superoxide dismutase-1 (SOD1) cause a familial form of ALS. Mutant SOD1-damaged glial cells contribute to ALS pathogenesis by releasing...

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Detalhes bibliográficos
Main Authors: Aebischer, J, Cassina, P, Otsmane, B, Moumen, A, Seilhean, D, Meininger, V, Barbeito, L, Pettmann, B, Raoul, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131923/
https://ncbi.nlm.nih.gov/pubmed/21072055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.143
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