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Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis

Pulmonary fibrosis is a vexing clinical problem with no proven therapeutic options. In the normal lung there is continuous collagen synthesis and collagen degradation, and these two processes are precisely balanced to maintain normal tissue architecture. With lung injury there is an increase in the...

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Bibliographic Details
Main Authors: McKleroy, William, Lee, Ting-Hein, Atabai, Kamran
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680761/
https://ncbi.nlm.nih.gov/pubmed/23564511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00418.2012
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