Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages

Milk fat globule epidermal growth factor 8 (Mfge8) is a soluble glycoprotein known to regulate inflammation and immunity by mediating apoptotic cell clearance. Since fibrosis can occur as a result of exaggerated apoptosis and inflammation, we set out to investigate the hypothesis that Mfge8 might ne...

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Hauptverfasser: Atabai, Kamran, Jame, Sina, Azhar, Nabil, Kuo, Alex, Lam, Michael, McKleroy, William, DeHart, Greg, Rahman, Salman, Xia, Dee Dee, Melton, Andrew C., Wolters, Paul, Emson, Claire L., Turner, Scott M., Werb, Zena, Sheppard, Dean
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786804/
https://ncbi.nlm.nih.gov/pubmed/19884654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40053
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