Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion

Mucus clearance is an important component of the lung's innate defense system. A failure of this system brought on by mucus dehydration is common to both cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Mucus clearance rates are regulated by the volume of airway surface li...

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Main Authors: Tarran, Robert, Sabater, Juan R., Clarke, Tainya C., Tan, Chong D., Davies, Catrin M., Liu, Jia, Yeung, Arthur, Garland, Alaina L., Stutts, M. Jackson, Abraham, William M., Phillips, Gary, Baker, William R., Wright, Clifford D., Wilbert, Sibylle
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680760/
https://ncbi.nlm.nih.gov/pubmed/23542952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00292.2012
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