Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion

Mucus clearance is an important component of the lung's innate defense system. A failure of this system brought on by mucus dehydration is common to both cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Mucus clearance rates are regulated by the volume of airway surface li...

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Autori principali: Tarran, Robert, Sabater, Juan R., Clarke, Tainya C., Tan, Chong D., Davies, Catrin M., Liu, Jia, Yeung, Arthur, Garland, Alaina L., Stutts, M. Jackson, Abraham, William M., Phillips, Gary, Baker, William R., Wright, Clifford D., Wilbert, Sibylle
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680760/
https://ncbi.nlm.nih.gov/pubmed/23542952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00292.2012
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