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Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion

Mucus clearance is an important component of the lung's innate defense system. A failure of this system brought on by mucus dehydration is common to both cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Mucus clearance rates are regulated by the volume of airway surface li...

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Detalhes bibliográficos
Main Authors: Tarran, Robert, Sabater, Juan R., Clarke, Tainya C., Tan, Chong D., Davies, Catrin M., Liu, Jia, Yeung, Arthur, Garland, Alaina L., Stutts, M. Jackson, Abraham, William M., Phillips, Gary, Baker, William R., Wright, Clifford D., Wilbert, Sibylle
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680760/
https://ncbi.nlm.nih.gov/pubmed/23542952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00292.2012
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