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Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors

Many inflammatory diseases may be linked to pathologically elevated signaling via the receptor for lipopolysaccharide (LPS), toll-like receptor 4 (TLR4). There has thus been great interest in the discovery of TLR4 inhibitors as potential anti-inflammatory agents. Recently, the structure of TLR4 boun...

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書誌詳細
主要な著者: Neal, Matthew D., Jia, Hongpeng, Eyer, Benjamin, Good, Misty, Guerriero, Christopher J., Sodhi, Chhinder P., Afrazi, Amin, Prindle, Thomas, Ma, Congrong, Branca, Maria, Ozolek, John, Brodsky, Jeffrey L., Wipf, Peter, Hackam, David J.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680486/
https://ncbi.nlm.nih.gov/pubmed/23776545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065779
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