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Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors

Many inflammatory diseases may be linked to pathologically elevated signaling via the receptor for lipopolysaccharide (LPS), toll-like receptor 4 (TLR4). There has thus been great interest in the discovery of TLR4 inhibitors as potential anti-inflammatory agents. Recently, the structure of TLR4 boun...

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Detalhes bibliográficos
Main Authors: Neal, Matthew D., Jia, Hongpeng, Eyer, Benjamin, Good, Misty, Guerriero, Christopher J., Sodhi, Chhinder P., Afrazi, Amin, Prindle, Thomas, Ma, Congrong, Branca, Maria, Ozolek, John, Brodsky, Jeffrey L., Wipf, Peter, Hackam, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680486/
https://ncbi.nlm.nih.gov/pubmed/23776545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065779
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