Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors

Many inflammatory diseases may be linked to pathologically elevated signaling via the receptor for lipopolysaccharide (LPS), toll-like receptor 4 (TLR4). There has thus been great interest in the discovery of TLR4 inhibitors as potential anti-inflammatory agents. Recently, the structure of TLR4 boun...

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Autors principals: Neal, Matthew D., Jia, Hongpeng, Eyer, Benjamin, Good, Misty, Guerriero, Christopher J., Sodhi, Chhinder P., Afrazi, Amin, Prindle, Thomas, Ma, Congrong, Branca, Maria, Ozolek, John, Brodsky, Jeffrey L., Wipf, Peter, Hackam, David J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680486/
https://ncbi.nlm.nih.gov/pubmed/23776545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065779
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