Toll-like Receptor 4 Is Expressed on Intestinal Stem Cells and Regulates Their Proliferation and Apoptosis via the p53 Up-regulated Modulator of Apoptosis

Factors regulating the proliferation and apoptosis of intestinal stem cells (ISCs) remain incompletely understood. Because ISCs exist among microbial ligands, immune receptors such as toll-like receptor 4 (TLR4) could play a role. We now hypothesize that ISCs express TLR4 and that the activation of...

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Bibliografiset tiedot
Päätekijät: Neal, Matthew D., Sodhi, Chhinder P., Jia, Hongpeng, Dyer, Mitchell, Egan, Charlotte E., Yazji, Ibrahim, Good, Misty, Afrazi, Amin, Marino, Ryan, Slagle, Dennis, Ma, Congrong, Branca, Maria F., Prindle, Thomas, Grant, Zachary, Ozolek, John, Hackam, David J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Molecular Bases of Disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481327/
https://ncbi.nlm.nih.gov/pubmed/22955282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.375881
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