Toll-like Receptor 4 Is Expressed on Intestinal Stem Cells and Regulates Their Proliferation and Apoptosis via the p53 Up-regulated Modulator of Apoptosis

Factors regulating the proliferation and apoptosis of intestinal stem cells (ISCs) remain incompletely understood. Because ISCs exist among microbial ligands, immune receptors such as toll-like receptor 4 (TLR4) could play a role. We now hypothesize that ISCs express TLR4 and that the activation of...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Neal, Matthew D., Sodhi, Chhinder P., Jia, Hongpeng, Dyer, Mitchell, Egan, Charlotte E., Yazji, Ibrahim, Good, Misty, Afrazi, Amin, Marino, Ryan, Slagle, Dennis, Ma, Congrong, Branca, Maria F., Prindle, Thomas, Grant, Zachary, Ozolek, John, Hackam, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481327/
https://ncbi.nlm.nih.gov/pubmed/22955282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.375881
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky